Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Hospices Civils de Lyon
With
GlaxoSmithKline
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Patient aged ≥ 18 years
2. Severe asthma diagnosed by a pulmonologist and followed for at least a year
3. Blood eosinophilia ≥ 0.15 G / L in the 12 months preceding inclusion in the trial.
4. At least 2 exacerbations in the past 12 months, each time treated with oral corticosteroid therapy or an increase in dosage of oral corticosteroid therapy prescribed for a long time, for at least 72 hours.
5. High dose inhaled corticosteroid therapy (\> 800 μg / d budesonide,\> 500 μg / d fluticasone,\> 1000 μg / d beclometasone, etc.) and at least one second controller asthma treatment with Long-Acting Beta-Agonists or Long-Acting Muscarinic Antagonists
6. Patient must have an efficient contraception method
7. Patient affiliated to a social security scheme.
8. Patient able to give free, informed and written consent.
You may not be if
1. Pregnant woman (urinary beta-HCG positive at inclusion) or breastfeeding
2. Active smoking or ex-smoking for less than 6 months and more than 10 pack-years
3. Exacerbation in the 4 weeks preceding first Mepolizumab injection
4. Patient who has already been treated with Mepolizumab or another anti-IL-5 or -5R treatment
5. Patient currently using a biotherapy indicated in severe asthma other than anti-IL5 or 5R treatments or stopped for less than 2 months
6. Treatment underway with another biotherapy not indicated for severe asthma
7. Patient participating in other interventional research, excluding routine care research (old regulation) and category 2 research not interfering with primary endpoint analysis
9. Any other uncontrolled chronic pathology, the presence of which would be considered incompatible with the performance of the study by the investigator
10. Patient under guardianship, curatorship or legal protection
