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TERMINATEDNA

Exercise for Better Bones - Day or Night?

Bone Metabolic Responses to Morning Versus Evening Exercise

NCT05612412•USDA Grand Forks Human Nutrition Research Center

Summary

The purpose of this study is to find out if moderate exercise at different time during the day (early morning vs early evening) affects biomarker CTX of bone health in normal to overweight postmenopausal women.

Detailed Description

The overall objective of this study is to investigate whether the daily timing of exercise affects bone turnover markers in postmenopausal women. Results from this clinical trial will provide valuable information to support guidelines of physical activity for people to improve musculoskeletal health, especially post-menopausal women. The scientific questions that will be investigated are: 1. What are the acute effects of the daily timing of exercise on serum concentrations of bone turnover markers and 24-h total urinary calcium excretion? 2. Are differences in initial exercise-induced responses of bone turnover markers and urinary Ca excretion maintained across two weeks of exercise training?

Eligibility

Age

45 - 65 years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•Postmenopausal women within 1-10 yr after menopause
•BMI 18.5-29.9 kg/m2
•Healthy as determined by a screening physical examination and blood chemistry related to thyroid, liver, kidney, and lipid profile within normal range
•No osteoporosis as determined by dual energy x-ray absorptiometry (DEXA) scan at femoral neck or total spinal region
•No regular exercise for more than 30 minutes a day on more than 2 days a week and no physically active employment, such as maintenance and repair or delivery worker
•No regular use of medications known to interfere with calcium and bone metabolism from 6 weeks prior to the study to the end of study such as medications for heartburn, reflux, H2 blockers, diuretics, etc. such as antacids, Maalox, Pepcid AC, Nexium, Diuril, etc.
•Weight stable (within 5 lbs change) for at least 3 months prior to the start of the study
•Willing to maintain usual lifestyle and activities including the same wake-sleep schedule (go to sleep between 10:00 p.m. and midnight with an average 6-8 hours of sleep time)
•Refrain from the use of alcohol and nicotine (for example, cigarettes, cigars, and e-cigarettes) for the length of the study
•Able and willing to perform moderate intensity exercise without contraindications as determined by the Physical Activity Readiness Questionnaire
+2 more criteria

Exclusion Criteria

•Hypertension with resting blood pressure higher than systolic 140 and diastolic 90 mmHg
•Within past 6 weeks, had nutrition supplements or medications known to affect calcium metabolism and appetite such as Antacids, Megace, antacids, heartburn, reflux, H2 blockers, diuretics, etc.
•Allergy to any food ingredients used in the provided diet
•Any disorders affecting nutrient absorption or metabolism, such as cystic fibrosis, lactose intolerance, celiac disease, etc.
•Any sleep disorders such as sleep apnea or regular use of an over-the-counter melatonin supplement
•Diabetes or taking medications known to affect bone such as Actos, Avandia, Invokana, etc.
•Engaged in moderate to vigorous exercise or regular exercise for more than 30 minutes/day on more than 2 days/week within past 6 weeks
•Repeated non-compliance with completing prescribed exercise sessions
•Within past 6 weeks, used tanning booths or traveled to location with a tropic climate
•Use of antibiotics (Amoxicillin, doxycycline, etc.), nonsteroidal anti-inflammatory drugs (aspirin, Celebrex, etc.), or probiotics (Lactobacillus, Bifidobacterium) within the past 6 weeks
+1 more criteria

Locations (1)

USDA Grand Forks Human Nutrition Research Center

Grand Forks, North Dakota, United States

Key Dates

Start Date

October 5, 2023

Primary Completion Date

July 30, 2024

Completion Date

July 30, 2024

Last Updated

April 11, 2025

Enrollment

ACTUAL participants

Conditions

Overweight

Interventions

Morning Exercise

OTHER

Evening Exercise

OTHER

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RECRUITINGNA

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 11, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Exercise for Better Bones - Day or Night?

Inclusion Criteria

Exclusion Criteria

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