Effects of Minocycline on Patients With Ischemic Stroke Undergoing Intravenous Thrombectomy

Exclusion Criteria

• •1. There are contraindications for mechanical thrombectomy;
• •2. No revascularization therapy was performed during the operation or the TICI score after revascularization therapy was less than 2b;
• •3. There are other major central nervous system diseases, such as brain injury, brain tumor, multiple sclerosis, etc;
• •4. There is evidence that the patient has bacterial endocarditis, aortic dissection, arteritis or venous cerebral infarction;
• •5. Renal insufficiency or hepatic insufficiency (serum creatinine \>2.0 mg/dL or 180 µmol/L; liver function greater than 3 times the normal value);
• •6. Known history of congestive heart failure (requiring dietary or medication changes or hospitalization) within 6 months, or myocardial infarction within 6 months;
• •7. There is evidence of any other life-threatening or severe diseases that may hinder the completion of the 3-month follow-up and affect the evaluation of the results;
• •8. Pre-existing neurological deficits or history of dementia;
• •9. There are infectious diseases that require antibiotic treatment before the disease;
• •10. Allergic to tetracyclines or unable to take minocycline for other reasons;
• •11. Minocycline could not be given within 1 hour after recanalization;
• •12. Pregnant patients;
• •13. Participated in another clinical trial within 30 days before inclusion in the study.
• •14. Refuse to sign the informed consent form.