Transarterial Neoadjuvant Chemotherapy vs.Traditional Intravenous Chemotherapy For Locally Advanced Gastric Cancer With SOX+PD-1

Exclusion Criteria

• •Patients can not bear surgical procedure.
• •Pregnant or lactating women.
• •HER2 overexpression(+++) confirmed by immunohistochemistry.
• •Previous cytotoxic chemotherapy, radiotherapy or immunotherapy.
• •History of another malignancy within the last five years.
• •History of uncontrolled seizures, central nervous system disorders or psychiatric disability judged by the Investigator to be clinically significant precluding informed consent or interfering with compliance for oral drug intake.
• •Clinically significant (i.e. active) cardiac disease e.g. symptomatic coronary artery disease, New York Heart Association (NYHA) grade II or greater congestive heart failure or serious cardiac arrhythmia requiring medication or myocardial infarction within the last 12 months.
• •History of dysphagia, complete or partial gastrointestinal obstruction, active gastrointestinal bleeding and gastrointestinal perforation;
• •Organ allografts requiring immunosuppressive therapy.
• •Serious uncontrolled intercurrent infections or other serious uncontrolled concomitant disease.
• •Moderate or severe renal impairment: serum creatinine \> 1.5 x upper limit of normal (ULN).
• •Hypersensitivity to any drug of the study regimen.
• •With abdominal cavity implantation metastasis or distant metastasis.
• •Unwilling or unable to comply with the protocol for the duration of the study.