Safety and Target Engagement of Centella Asiatica in Cognitive Impairment

Exclusion Criteria

• •Current smoking, alcohol, or substance abuse according to DSM-V criteria
• •Women who are pregnant, planning to become pregnant, or breastfeeding
• •Men who are actively trying to conceive a child or planning to within three months of study completion
• •Severe aversion to venipuncture
• •Abnormal labs indicating asymptomatic and untreated urinary tract infection
• •Cancer within the last five years, with the exception of localized prostate cancer (Gleason Grade \< 3) and non-metastatic skin cancers
• •Comorbid conditions such as type I diabetes mellitus, poorly controlled type II diabetes mellitus (HbA1c \> 7%), kidney failure, liver failure, hepatitis, blood disorders, clinical symptomatic orthostatic hypotension, and unstable or significantly symptomatic cardiovascular disease
• •Significant disease of the Central Nervous System (CNS) such as brain tumor, seizure disorder, subdural hematoma, cranial arteritis, or clinically significant stroke
• •Major depression, schizophrenia, or other major psychiatric disorder defined by DSM-V criteria
• •Medications: anti-epileptics, sedatives, amitriptyline, anticoagulants (e.g., warfarin), investigational drugs used within five half-lives of baseline visit, systemic corticosteroids, neuroleptics, anti-Parkinsonian agents, narcotic analgesics, nicotine (tobacco, patches, gum, lozenges, etc.), Cannabis sativa (herb or edibles), beta blockers and anti-depressant medications that have not been at stable dosage for two months (including SSRIs, SNRIs)
• •Non-Alzheimer dementia such as vascular dementia, normal pressure hydrocephalus, or Parkinson's disease
• •MMSE score of \< 20 or \> 28
• •Unwilling to maintain stable dosage of AD medications throughout study duration
• •Unwilling to maintain stable dosage of intervention throughout the course of the study
• •Contraindications to Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopic Imaging (MRSI) scans (some metal implants, pacemakers, claustrophobia)