A Prospective Study of Conventional Bone Marrow Biopsy Versus Portomar(TM) Biopsy

Exclusion Criteria

• •• Patients with any other ongoing, concomitant, comorbid illness including but not limited to uncontrolled diabetes, NYHA class III or worse heart failure, uncontrolled coronary artery disease/arrhythmia.
• •* Patients unable to comply with the study schema.
• •* Confirmed pregnancy at time of screening or on implantation day prior to anesthesia/sedation.
• •* Patients unable to come off of anticoagulation medications for their procedure.
• •* Patients with active infection.
• •* Patients with \< 0.5 cm or \> 2.5 cm of soft tissue between screw head and skin at the target site of implantation. This is based on the patient's prior imaging studies (i.e. CT/MR or ultrasound imaging).
• •* Patient has contra-indication to conscious sedation or anesthesia services
• •* Patients who have had prior bone marrow biopsy within 2 weeks of the study biopsy.
• •* Patients with coagulopathy such that INR cannot be corrected \< 2.0.
• •* Patients who are prisoners or wards of the court.
• •* Patients with alcohol or substance abuse disorder defined by DSM V criteria.
• •* Patients with the diagnosis of a major psychiatric disorder such as schizophrenia or major depression defined by the DSM-V criteria.
• •* Patients with osteoporosis defined as L1 vertebrae bone density lower than 90 Hounsfield units