Effect of Perioperative Acetaminophen Dosing on Patients Undergoing Surgical Treatment of Basilar Thumb Arthritis

NCT05556356•Indiana Hand to Shoulder Center

Summary

Basilar thumb arthritis is a common problem that affects 7% of men and 15% of women. It is regarded as one of the more painful procedures commonly performed by hand surgeons. Opioid overuse and diversion are significant problems in the country that contribute to opioid addiction as well as deaths from opioid overdose. Prior studies have examined the effect of different nerve block compositions on perioperative and postoperative analgesia, but none have looked at perioperative loading analgesia. We will attempt to address this problem by exploring alternative analgesia regimens to decrease opioid prescribing after 1st carpometacarpal (CMC) joint arthroplasty.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Adults (18 years of age or older)
•Patients presenting with symptomatic 1st CMC arthritis with or without scaphotrapeziotrapezoid arthritis
•Eaton Classification stage II, III, or IV OA of the first CMC joint based on xrays
•Patients who plan to undergo a ligament reconstruction and tendon interposition (LRTI) or thumb suspensionplasty procedure within 6 months of enrolling to study
•Bilateral thumbs included

Exclusion Criteria

•\<18 years age
•Prior surgical history of ipsilateral 1st CMC arthroplasty or procedures involving thumb CMC joints
•Prior ipsilateral tendon rupture or ipsilateral peripheral nerve palsy
•History of opioid dependency or current chronic opioid use
•Contraindication to acetaminophen use
•Contraindication to NSAID use
•Contraindication or known allergy to peripheral nerve blockade, including coagulopathy
•Contraindication to supraclavicular block due to anatomic variability or inability to tolerate phrenic nerve blockade.
•Contraindication to multivitamin use
•Liver dysfunction

Locations (1)

Indiana Hand to Shoulder Center

Indianapolis, Indiana, United States

Key Dates

Start Date

September 13, 2022

Primary Completion Date

May 6, 2024

Completion Date

May 6, 2024

Last Updated

October 8, 2024

Enrollment

ACTUAL participants

Conditions

Carpometacarpal Osteoarthritis

Interventions

Acetaminophen

DRUG

Placebo: Multivitamin

OTHER

ICF-Based Biopsychosocial Assessment With AI-Assisted Profile Prediction: Trapeziometacarpal Osteoarthritis Model

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Trapeziometacarpal OsteoarthritisThumb Osteoarthritis+2 more

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UNKNOWNNA

Trapeziectomy Suspensionplasty Versus Carpometacarpal Joint Replacement in Treatment of Basal Thumb Osteoarthritis

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 8, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effect of Perioperative Acetaminophen Dosing on Patients Undergoing Surgical Treatment of Basilar Thumb Arthritis

Inclusion Criteria

Exclusion Criteria

ICF-Based Biopsychosocial Assessment With AI-Assisted Profile Prediction: Trapeziometacarpal Osteoarthritis Model

Trapeziectomy Suspensionplasty Versus Carpometacarpal Joint Replacement in Treatment of Basal Thumb Osteoarthritis

An Open Label Trial for Treating Carpometacarpal Osteoarthritis of the Thumb: Pilot Study