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An Open Label Trial for Treating Carpometacarpal Osteoarthritis of the Thumb: Pilot Study | Clinical Trials | Clareo Health

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An Open Label Trial for Treating Carpometacarpal Osteoarthritis of the Thumb: Pilot Study

NCT00198029•Hospital for Special Surgery, New York

View on ClinicalTrials.gov

Summary

The purpose of this study is to find out if hyaluronan, an injectable medication for knee arthritis, also works for arthritis at the base of the thumb. This study will also evaluate how good ultrasound is at visualizing medication in the thumb joint. We are no longer recruiting for this part of the open label trial.

Eligibility

Age

45 - 95 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Radiographic evidence of at least moderate narrowing (joint space \< 1mm) or the presence of osteophytes or sclerosis at the Carpometacarpal joint
•Patient complaint of unacceptable pain despite modification of activity, a trial of splinting and a therapeutic dose of NSAIDS
•If bilateral disease, only the most severely involved hand, (as defined by VAS for pain), will be entered in the study.
•Proficiency in English.

Exclusion Criteria

•Previous bad injury to the thumb
•Previous hand surgery on the study thumb
•Known hand comorbidities (i.e. carpal tunnel syndrome, de Quervains Tenosynovitis etc)
•Rheumatoid arthritis or lupus
•Bleeding problems
•Being on blood thinners (except aspirin)
•Known allergies to any of the medications being used
•Allergies to chicken products
•Current use of oral steroids
•Cancer that is not cured or in remission
+2 more criteria

Locations (1)

Hospital for Special Surgery

New York, New York, United States

Key Dates

Start Date

October 1, 2004

Primary Completion Date

December 1, 2009

Completion Date

December 1, 2009

Last Updated

April 17, 2017

Enrollment

ACTUAL participants

Conditions

Carpometacarpal Osteoarthritis

Interventions

Synvisc (hylan G-F20)

DEVICE

ICF-Based Biopsychosocial Assessment With AI-Assisted Profile Prediction: Trapeziometacarpal Osteoarthritis Model

NCT07458971

Trapeziometacarpal OsteoarthritisThumb Osteoarthritis+2 more

View study

TERMINATEDPHASE4

Effect of Perioperative Acetaminophen Dosing on Patients Undergoing Surgical Treatment of Basilar Thumb Arthritis

NCT05556356

Carpometacarpal Osteoarthritis

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 17, 2017Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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An Open Label Trial for Treating Carpometacarpal Osteoarthritis of the Thumb: Pilot Study

Inclusion Criteria

Exclusion Criteria

ICF-Based Biopsychosocial Assessment With AI-Assisted Profile Prediction: Trapeziometacarpal Osteoarthritis Model

Effect of Perioperative Acetaminophen Dosing on Patients Undergoing Surgical Treatment of Basilar Thumb Arthritis

Trapeziectomy Suspensionplasty Versus Carpometacarpal Joint Replacement in Treatment of Basal Thumb Osteoarthritis