Neuroimmune Mechanisms in Obesity

Exclusion Criteria

• •Abnormal labs including Creatinine\>1.5mg/dL, Hematocrit \< 35% for females and \< 39% for males, ALT/AST \>2.5X upper limit of normal, abnormal TSH
• •Known significant thyroid, hepatic, neurologic, psychiatric, cerebrovascular, or cardiovascular disease
• •\>5% body weight change in last 6 months
• •Current or recent regular steroid use in last 6 months, illicit drug use that is deemed to interfere with results including problematic alcohol use as defined by NIAAA
• •Current regular use of psychotropic and/or potentially psychoactive prescription medications
• •Regular use of any vitamins/supplements that could affect lipids
• •Current regular use of non-steroidal anti-inflammatory medications, statins, or lipid lowering agents
• •Vaccination in the last month
• •Individuals who are classified as "low binders" for the rs6971 polymorphism (\<10% of the population)
• •For females, physical or laboratory (-HCG) evidence of pregnancy, seeking pregnancy, or lactating. A urine drug screen and pregnancy test will be performed at screening and prior to the imaging session. Subjects who screen positive will be excluded.
• •Note: If a subject tests positive for an illicit substance, the PI will determine if the substance would interfere with the results and may terminate participation if applicable. Results of the test would only be noted in the subjects de-identified chart to document the occurrence.