ABTECT - Maintenance

Exclusion Criteria

• •Subjects who permanently discontinued the study treatment during the induction study (either ABX464-105 or ABX464-106).
• •Subjects who have developed any major illness/condition (eg. primary sclerosis cholangitis, Crohn's disease, colectomy, diverting ileostomy, colon cancer or colonic adenomas \[low or high grade dysplasia\]).
• •Subjects with evidence of an unstable clinical condition (eg. toxic megacolon, fulminant colitis, bowel perforation, uncontrolled ischemic disease, congestive heart failure with NYHA class 3 or 4 symptoms) during the induction study that, in the investigator's judgment, will substantially increase the risk to the subject if he or she participates in the study.
• •Subjects who plan to participate in other investigational studies during the maintenance study.
• •Male or female planning a pregnancy, or pregnant female subjects
• •Introduction during induction study of prohibited medications, dosages, surgical or non-medicinal procedures indicated for UC (except antidiarrheals and motility agents for acute diarrhea).
• •Any changes in the laboratory values during the induction period that could jeopardize subject's safety in the opinion of the investigator. If any doubts, the investigator should contact the sponsor study medical monitor.
• •Subject who is planning to receive live vaccine during the study.
• •Subjects committed to an institution by virtue of an order issued either by the judicial or the administrative authorities.
• •Introduction during maintenance phase of prohibited medications, dosages, surgical or non-medicinal procedures indicated for UC (except antidiarrheals and motility agents for acute diarrhea).