Study of ARO-RAGE in Healthy Subjects

Exclusion Criteria

• •Acute lower respiratory infection within 30 days prior to first dose and/or acute upper respiratory infection within 7 days prior to first dose
• •Positive COVID-19 test during Screening window
• •Chronic or acute infection that is clinically significant or requires treatment with systemic antibiotics, antivirals, antifungals, or antiparasitics within 30 days prior to first dose
• •Any history of chronic pulmonary disease
• •Use of immunosuppressive medication within 90 days prior to first dose
• •Receipt of any intranasal vaccine within 30 days prior to first dose
• •Human Immunodeficiency virus (HIV) infection, seropositive fo Hepatitis B Virus (HBV), seropositive for Hepatitis C Virus (HCV)
• •Uncontrolled hypertension
• •Use of illicit drugs
• •Unwilling to limit alcohol consumption to within moderate limits for the duration of the study
• •Use of an investigational agent or device within 30 days prior to first dose
• •Prior use of any formulation of ARO-RAGE