Multi-factor Model Constraction for Early Warning and Diagnosis of MDD

The immune imbalance has been reported in patients with unipolar and bipolar depression. There is no unified conclusion in the field and severity of the immune imbalance, and the cause of cognitive impairment is unknown, which may be related to many factors. Omega-3 fatty acids are immune modulators that possess antidepressant effects. This study includes three steps. 1. We will enroll bipolar and major depressive disorder patients who are in a depressive episode and enroll healthy controls. All subjects will be assessed at baseline 2. We will give omega-fatty acid treatment based on immune indicators 3. The follow-up will last for one year with five sessions.