Efficacy and Safety of a Probiotic Formulation in Adults With Irritable Bowel Syndrome With Diarrhea (IBS-D)

Exclusion Criteria

• •A history of inflammatory or immune-mediated gastrointestinal diseases
• •Diagnosed with a co-existing organic gastrointestinal disease which can affect the study
• •Currently undergoing a treatment for other severe conditions such as coronary disease, neurological disorder, kidney or liver disease,
• •Currently diagnosed with an eating disorder,
• •Having undergone any abdominal surgery including cholecystectomy, with the exception of hernia repair or appendectomy
• •Currently diagnosed with any mood- or anxiety-related disorder, major psychiatric illness, or participants with a history of suicidal ideation, or current suicidal ideation,
• •Regular use of anti-diarrhea medications and laxatives however occasional use is permitted (≤ than once a month); if current use is \> once per month a one month wash out is needed,
• •Unwilling to avoid the use of antidiarrheal or laxative medication on an "as-needed basis" during the full length of the study,
• •Pregnant, breast-feeding or planning on becoming pregnant.