The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Inclusion Criteria

• •Meets IOM ME/CFS case definition criteria,
• •Co-morbid IBS: meets RomeIV criteria for alternating or diarrhea-predominant IBS as reported during screening (technically diagnosed by a physician),
• •Able to provide consent to study,
• •Patients of childbearing potential must practice effective contraception during the study and be willing to continue contraception for at least six months after the intervention,
• •agrees to participate in online surveys and follow-up visits.
• •Probiotics in the past eight weeks,
• •Antibiotics in the past eight weeks,
• •Pregnancy or lactating women,
• •Medical conditions including short bowel syndrome, celiac disease, biliary disease, pancreatitis, inflammatory bowel disease (Crohn's disease, ulcerative colitis), severe cardiovascular, neurological condition, or liver failure,
• •Gastrointestinal surgery within six months of study entry,
• •History of psychiatric disorder, alcohol or illicit drug abuse.