ABTECT-1 - ABX464 Treatment Evaluation for Ulcerative Colitis Therapy -1

Exclusion Criteria

• •Subjects with UC limited to an isolated proctitis (≤ 15cm from anal verge) determined by endoscopy central reading.
• •Subjects with primary sclerosing cholangitis or autoimmune hepatitis.
• •Subjects who have failed on 5-ASA or sulfasalazine therapy only.
• •Subjects with CD or presence or history of fistula, indeterminate colitis, infectious/ischemic colitis or microscopic colitis (lymphocytic and collagenous colitis).
• •History or current evidence of toxic megacolon, fulminant colitis, bowel perforation.
• •History of colonic cancer or colonic low grade or high grade dysplasia adenomatous polyps, and/or at the screening endoscopy, evidence of colonic cancer or evidence of low grade or high grade dysplasia adenomatous polyps (fully removed or not).
• •Recent or planned bowel surgery or history of proctocolectomy or partial colectomy or current stoma.
• •Subjects on antidiarrheals including those working on motility (e.g., loperamide, diphenoxylate with atropine, etc.).
• •Subjects on probiotics (e.g., Culturelle® \[Lactobacillus GG, i-Health, Inc.\], Saccharomyces boulardii).
• •Subjects who do not meet the washout period requirements prior to the screening endoscopy
• •Subjects with the following hematological and biochemical laboratory parameters obtained during the screening period:
• •* Hemoglobin ≤ 8.0 g dL-1
• •* Absolute neutrophil count \< 750 mm-3
• •* Platelets \< 100,000 mm-3
• •* Creatinine clearance \< 60 mL.min-1 (Cockroft-Gault formula)
• •* Total serum bilirubin \> 1.5 x ULN
• •* Alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \> 2 x ULN
• •Subjects with the following conditions (infection):
• •* Subjects with chronic or recurrent grade 3 or grade 4 infection within the last 2 months prior to screening or a history of opportunistic infection while not on immunosuppressive therapy.
• •* Herpes zoster reactivation within the last 2 months prior to screening.
• •* Subjects with active infection at screening or any major episode of infection that required hospitalization or treatment with intravenous antibiotics within 1 month of screening or during screening. Fungal infection of nail beds is allowed.
• •* Positive assay or stool culture for pathogens (ova and parasite examination, bacteria) or positive test for Clostridium difficile toxin at screening. If C. difficile is positive, subject may be treated and retested ≥ 2 weeks after completing treatment.
• •* Subjects with HIV infection.
• •* Subjects having acute or chronic hepatitis B infection at screening (positive for hepatitis B surface antigen \[HbsAg\], or negative for HbsAg and positive for anti-hepatitis B core antibody in conjunction with detectable HBV DNA, or detectable HBV DNA).
• •* Subjects having acute or chronic hepatitis C infection at screening as defined by positive for hepatitis C antibody (subjects successfully treated and without recurrence ≥ 1 year with no detectable HCV RNA \[assessed centrally\] are eligible).
• •* Active tuberculosis (TB) or untreated latent TB are ruled out. For subjects with positive or intermediate QuantiFERON test see study protocol.
• •Subjects with an uncontrolled ischemic heart disease and/or a history of congestive heart failure with New York Heart Association (NYHA) class 3 or 4 symptoms.
• •Subjects with a family or personal history of congenital or acquired long QT syndrome, or subjects with a marked baseline prolongation of QT/QTc interval (e.g., repeated demonstration of a QTc interval \[Fridericia or Bazett correction\] \>450 milliseconds for male and \> 460 milliseconds for female).
• •Subjects with a history of torsade de pointe (TdP).
• •Acute or chronic of clinically relevant pulmonary, hepatic, pancreatic or renal functional abnormality, encephalopathy, neuropathy or unstable central nervous system pathology such as seizure disorder, or any other clinically significant medical problems as determined by physical examination and/or laboratory screening tests and/or medical history (note: treated autoimmune hypothyroidy and autoimmune diabetes are allowed).
• •Serious illness requiring hospitalization within 4 weeks prior to screening (except UC flare).
• •Subjects previously treated with ABX464.
• •Subjects with a known hypersensitivity to the active substance or to any of the excipients.
• •WOCBP subject who is pregnant or breast-feeding at screening, or intends to become pregnant during the study, or male subject with WOCBP partner who intends to be pregnant during the study.
• •Illicit drug or alcohol abuse or dependence.
• •Subjects who received live vaccine within 3 months prior to screening and/or who's planning to receive such a vaccine during the study duration.
• •Use of any investigational or non-registered product within 3 months or within 5 half-lives preceding baseline, whichever is longer, and during the study.
• •Subjects committed to an institution by virtue of an order issued either by the judicial or the administrative authorities.
• •Any condition, which in the opinion of the investigator, could compromise the subject's safety or adherence to the study protocol.