Functional Cure Rate of Peg-IFNα-2b Combined With TAF in HBeAg Negative CHB Patients

Exclusion Criteria

• •Known allergy to interferon, nucleos(t)ide drugs, or any ingredient of the drug.
• •Currently co-infection with HAV, HCV, HDV, HEV, HIV, or any other virus.
• •Cirrhosis or Child-Pugh score of 7 or above.
• •Liver disease caused by other reasons (eg. autoimmune liver disease, alcoholic liver disease, nonalcoholic fatty liver disease, drug-induced hepatitis, hepatolenticular degeneration, etc.).
• •Pregnant or lactating women.
• •Alcoholism or drug abuse within one year prior to the screening.
• •Neutrophil count\<1.5×10\^9/L, hemoglobin\<100g/L, or platelet count\<80×10\^9/L.
• •Serum creatinine was higher than the upper limit of normal at screening.
• •History of serious disease in heart, brain, kidney, retina, muscle, or other major organ and systems.
• •Have a history of mental illness or family history of mental illness, or Hamilton Depression Scale score ≥ 7 points.
• •Have a history of endocrine system or autoimmune diseases, such as thyroid disease, systemic lupus erythematosus, sarcoidosis, autoimmune thrombocytopenic purpura, psoriasis, etc.
• •Chronic diseases requiring long-term treatment, such as uncontrolled hypertension, diabetes, chronic obstructive pulmonary disease, etc.
• •Malignant tumor.
• •Suspected hepatocellular carcinoma in B-ultrasound at screening; or fetoprotein alpha was greater than 100ng/ml, or cannot remain stable within 3 months before screening.
• •Accepted organ transplantation previously.
• •Other reasons that the investigator considers unsuitable for inclusion.