Elranatamab Expanded Access Protocol in Adults With Relapsed/Refractory Multiple Myeloma

Inclusion Criteria

• •Prior diagnosis of MM as defined according to IMWG criteria .
• •Patients who are ineligible for participation in any ongoing clinical trial of elranatamab, including lack of access due to geographical limitations, and who have exhausted all other treatment options or experience lack of access to commercially available therapies due to geographical, financial or socioeconomic limitations.
• •Measurable disease at screening based on IMWG criteria as defined by at least 1 of the following:
• •Serum M-protein ≥0.5 g/dL (≥5 g/L)
• •Urinary M-protein excretion ≥200 mg/24 hours
• •Involved FLC ≥10 mg/dL (≥100 mg/L) AND abnormal serum immunoglobulin kappa to lambda FLC ratio (\<0.26 or \>1.65).
• •Refractory to at least one IMiD, one PI, and one anti-CD38 antibody.
• •Relapsed/refractory to last anti-MM regimen.
• •ECOG performance status 0-1.
• •Resolved acute effects of any prior therapy to baseline severity or CTCAE Grade ≤1.
• •Not pregnant, willing to use contraception