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A PHASE 3, OPEN-LABEL STUDY OF ELRANATAMAB MONOTHERAPY VERSUS ELOTUZUMAB, POMALIDOMIDE, DEXAMETHASONE (EPd) OR POMALIDOMIDE, BORTEZOMIB, DEXAMETHASONE (PVd) OR CARFILZOMIB, DEXAMETHASONE (Kd) IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA WHO RECEIVED PRIOR ANTI-CD38 DIRECTED THERAPY
The purpose of this study is to learn about the study medicine called elranatamab.This study aims to compare elranatamab to other medicines for the treatment of MM (a type of cancer). This study is seeking participants who: * Are 18 years of age or older and have MM. * Have received treatments before for MM. * Have MM that has returned or not responded to their most recent treatment. Half of the participants will receive elranatamab. The other half of participants will receive a combination therapy selected by the study doctor. The selected combination therapy will include 2 to 3 different medicines commonly used to treat MM. Elranatamab will be given as a shot under the skin at the study clinic about once a week. This may change to a smaller number of shots later in the study. The medicines in the combination therapy will be taken by mouth (at home or at the study clinic) AND will be given either as: * a shot under the skin at the study clinic * through a needle in the vein at the study clinic The number of times these medicines will be taken depends on what combination therapy the study doctor selects. Participants may continue to receive elranatamab or a combination therapy until their MM is no longer responding. The study team will see how each participant is doing with the study treatment during regular visits at the study clinic. The study team will continue to follow-up with participants after study treatment with telephone contacts (or visits). The study will compare the experiences of people receiving elranatamab to those people receiving a combination therapy. This will help learn about the safety and how effective elranatamab is.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Infirmary Cancer Care
Mobile, Alabama, United States
Western Regional Medical Center, Inc. dba. City of Hope Phoenix
Goodyear, Arizona, United States
Beverly Hills Cancer Center
Beverly Hills, California, United States
Community Cancer Institute
Clovis, California, United States
Clinical Research Advisors (Encino Satellite Location)
Encino, California, United States
Hoag Health Center Irvine
Irvine, California, United States
Hoag Hospital Irvine
Irvine, California, United States
Clinical Research Advisors (Korea Town Satellite Location)
Los Angeles, California, United States
Clinical Research Advisors (West Hollywood Satellite Location)
Los Angeles, California, United States
Valkyrie Clinical Trials
Los Angeles, California, United States
Start Date
February 8, 2024
Primary Completion Date
August 30, 2026
Completion Date
December 30, 2027
Last Updated
March 20, 2026
492
ESTIMATED participants
Elranatamab
DRUG
Elotuzumab
DRUG
Pomalidomide
DRUG
Dexamethasone
DRUG
Bortezomib
DRUG
Carfilzomib
DRUG
Lead Sponsor
Pfizer
NCT06179888
NCT04973605
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT05201781