High Molecular Weight Hyaluronic Acid, α-lipoic Acid, Magnesium, Vitamin B6 and Vitamin D, in the Prevention of Spontaneous Abortion

Efficacy of the Association of Hyaluronic Acid With High Molecular Weight, α-lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D, in the Prevention of Spontaneous Abortion in Patients at Risk

NCT05449171•Lo.Li.Pharma s.r.l

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Summary

The study aims to verify if the association of high molecular weight hyaluronic acid, α-lipoic acid (ALA), magnesium, vitamin B6 and vitamin D, reduces the risk of miscarriage in patients at risk.

Eligibility

Age

18 - 45 years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•two or more previous spontaneous first trimester abortions without apparent risk factors (idiopathic polyabortion)
•Endocrinopathies
•Autoimmune diseases
•Thrombophililic or coagulation diseases

Exclusion Criteria

•Multiple pregnancies
•Presence of genetic abnormalities of one or both partners leading to increased risk of fetal aneuploidies
•Presence of Mullerian abnormalities in the uterus
•Symptoms present at recruitment such as pelvic pain or metrorrhagia

Locations (1)

Dipartimento di Neuroscienze e Scienze riproduttive ed odontostomatologiche

Naples, Italy

Key Dates

Start Date

September 1, 2022

Primary Completion Date

September 1, 2023

Completion Date

January 31, 2024

Last Updated

February 22, 2024

Enrollment

100

ACTUAL participants

Conditions

Abortion, Spontaneous

Interventions

high molecular weight hyaluronic acid, α-lipoic acid (ALA), magnesium, vitamin B6 and vitamin D

OTHER

Intralipid for Recurrent Miscarriage

NCT01788540

Abortion, SpontaneousAbortion, Habitual

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COMPLETED

Internet-based Study of Fertility and Early Pregnancy (PEEPS)

NCT01904669

FertilityInfertility+2 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 22, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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