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Intralipid for Recurrent Miscarriage | Clinical Trials | Clareo Health

COMPLETEDPHASE4

Intralipid for Recurrent Miscarriage

The Role of Intralipid in Natural Killer Cell Positive Cases With Recurrent Miscarriages Undergoing IVF/ICSI Cycles: a Double Blind Randomized Controlled Trial

NCT01788540•Woman's Health University Hospital, Egypt

View on ClinicalTrials.gov

Summary

Intralipid infusion can improve the outcome in NK cells positive females with history of recurrent miscarriages undergoing IVF/ICSI cycles.

Eligibility

Age

18 - 40 years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•Couples with unexplained secondary infertility
•Three or more prior consecutive clinical miscarriages after either spontaneous pregnancy or after IVF/ICSI.
•Elevated natural killer (NK) cells CD16, CD56 and cells with both CD16/CD56 \>12%.

Exclusion Criteria

•Age above forty years old.
•Antiphospholipid syndrome (lupus anticoagulant and/or anticardiolipin antibodies \[IgG or IgM\]); other recognised thrombophilic conditions (testing according to usual clinic practice).
•Intrauterine abnormalities (as assessed by ultrasound, hysterosonography, hysterosalpingogram, or hysteroscopy).
•Abnormal parental karyotype.
•Other identifiable causes of recurrent miscarriages (tests initiated only if clinically indicated) e.g., diabetes, thyroid disease and systemic lupus erythematosus (SLE).
•Disturbances of normal fat metabolism such as pathologic hyperlipemia
•Allergic to it; or to eggs, soybean oil, or safflower oil.
•Severe liver disease, kidney disease, lung disease, anemia, blood clotting disorder.

Locations (1)

Kasr el ainy hospital

Cairo, Egypt

Key Dates

Start Date

February 1, 2013

Primary Completion Date

August 1, 2016

Completion Date

September 1, 2016

Last Updated

January 26, 2018

Enrollment

300

ESTIMATED participants

Conditions

Abortion, SpontaneousAbortion, Habitual

Interventions

Intralipid

DRUG

Autologous Decidual-like Natural Killer Cells Therapy for Infertility or Adverse Pregnancy History

NCT06821685

Abortion, HabitualInfertility Unexplained+2 more

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NOT_YET_RECRUITINGPHASE3

LIGHT Trial: Levothyroxine for Gestational Hypothyroidism in Recurrent Pregnancy Loss

NCT06999278

Abortion, Habitual

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 26, 2018Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Intralipid for Recurrent Miscarriage

Inclusion Criteria

Exclusion Criteria

Autologous Decidual-like Natural Killer Cells Therapy for Infertility or Adverse Pregnancy History

LIGHT Trial: Levothyroxine for Gestational Hypothyroidism in Recurrent Pregnancy Loss

High Molecular Weight Hyaluronic Acid, α-lipoic Acid, Magnesium, Vitamin B6 and Vitamin D, in the Prevention of Spontaneous Abortion

Internet-based Study of Fertility and Early Pregnancy (PEEPS)