A Prospective Cohort Study of Exercise Rehabilitation in the Treatment of Parkinson's Disease

Exclusion Criteria

• •1. Secondary causes, such as inflammatory, drug-induced, vascular and toxin-induced parkinsonism.
• •2. Parkinsonism with other neurodegenerative diseases, such as progressive supranuclear palsy, multiple system atrophy, cortical basal ganglia degeneration, Wilson's disease.
• •3. Other neurological diseases, such as stroke.
• •4. Patients who were receiving any other clinical trials or regular exercise protocols.
• •5. Patients who had fall incidents in the 6 months before recruiting due to safety considerations.
• •6. Patients whose Mini-Mental State Examination (MMSE) scores were less than 24.
• •7. Patients who had medical history that did not fit to exercise, such as orthopedics diseases or cardiopulmonary dysfunction.
• •8. Patients who received education less than 6 years.
• •9. Patients who could not walk and live independently.
• •10. Patients who received brain surgery (e.g. deep brain stimulation);
• •11. Patients whose exercise length longer than 50 minutes per week.