Jun Liu, Professor

CONTACT

Lead Sponsor

Ruijin Hospital

Age

20 - 80 years

Sex

ALL

Healthy Volunteers

No

•Meet the revised clinical diagnostic criteria for Parkinson's disease of the Movement Disorder Society (MDS) International (2015 version).
•aged \>20 years and \<80 years, regardless of gender.
•2 ≤ Hoehn-Yahr stage≤ 4.
•Maintain medication stability during the study period.
•Good compliance, written informed consent, and consent for long-term interventional treatment with iTBS.

•Patients with severe neuropsychiatric disorders or previous history of severe neurological disorders (e.g., epilepsy, cerebrovascular accidents, etc.) or history of traumatic brain injury or brain surgery.
•Patients with significant cognitive impairment (MMSE \< 24) or inability to complete questionnaires independently.
•Prior treatment with TMS, DBS or SCS.
•Severe physical illness and any physical illness that can precipitate epilepsy or intracranial hypertension, including cardiovascular and respiratory disease.
•Have human implantable materials such as intracranial stents, pacemakers, coronary stents, cochlear implants, etc.
•Are currently taking other investigational drugs.
•Any other condition that the investigator deems unsuitable for participation in this study.