PROpranolol for Cerebral Hemorrhage-ASsociated pnEumonia (PRO-CHASE)

Exclusion Criteria

• •1. Subjects is considered a candidate for immediate surgical intervention by the neurosurgery service, including surgical evacuation of hematoma, decompressive craniectomy, minimally invasive aspiration of hematoma, and ventricular shunt or external ventricular drainage for intracerebral hemorrhage into the ventricle.
• •2. Patients with primary intraventricular hemorrhage or cerebral hemorrhage due to a definite cause, such as trauma, vascular malformation, aneurysm, coagulopathy, anticoagulant or antiplatelet drugs, thrombolytic therapy, post-infarction hemorrhagic transformation, hematologic disease, moyamoya disease, primary or metastatic tumor, venous sinus thrombosis, vasculitis, etc.
• •3. Previous stroke or pre-onset motor disability (mRS≥1)
• •4. Pregnancy or parturition within previous 30 days or active lactation.
• •5. Use of beta blockers (propranolol, metoprolol, sotalol, carvedilol, bisoprolol, atenolol, esmolol, etc.) or reserpine within the last 30 days.
• •6. Bronchial asthma or chronic obstructive pulmonary disease
• •7. Cardiogenic shock or severe or acute heart failure.
• •8. Degree II-III atrioventricular block or sinus bradycardia or heart rate ≤65/min.
• •9. Known sensitivity to propranolol.
• •10. Severe hepatic or renal insufficiency
• •11. History of Malignancy
• •12. Currently participating in other interventional clinical trials.
• •13. Immunosuppressant therapy or known immunosuppression.