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COMPLETEDEARLY_PHASE1

Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social Function

NCT05379959•University of Chicago

Summary

To study the effects of MDMA, compared to a prototypical stimulant, on social motivation, social ability, and neural indices of social function in healthy volunteers

Eligibility

Age

18 - 40 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•BMI between 19 and 30 (no one under 130 lbs)
•Smokers smoking less than 25 cigarettes per week
•Have used ecstasy no more than 40 times with no adverse responses.

Exclusion Criteria

•High blood pressure
•Any medical condition requiring regular medication
•Individuals with a current (within the last year) DSM-IV Axis 1 diagnosis
•Individuals with a history of dependence on stimulant drugs.
•Women who are pregnant or trying to become pregnant

Locations (1)

University of Chicago

Chicago, Illinois, United States

Key Dates

Start Date

May 11, 2022

Primary Completion Date

October 24, 2022

Completion Date

October 24, 2023

Last Updated

January 24, 2024

Enrollment

ACTUAL participants

Conditions

Stimulant UseMDMA ('Ecstasy')Social BehaviorMotivation

Interventions

MDMA

DRUG

Methamphetamine

DRUG

placebo oral tablet

DRUG

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RECRUITINGNA

Project neuroARTEMIS

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 24, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social Function

Inclusion Criteria

Exclusion Criteria

Optimizing Transcranial Magnetic Stimulation for Stimulant Use Disorder

Enhancing Prospective Thinking in Early Recovery

Project neuroARTEMIS

A Clinical Trial to Evaluate the Safety and Efficacy of Neuromodulation Using 'ExAblate 4000 Type 2.1' in Patients With Psychostimulant Use Disorder(PUD)

Implementing Contingency Management for Stimulant Use in Specialty Addiction Treatment Organizations

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