Orexin Receptor Antagonism and Sleep in Stimulant Use Disorder

Exclusion Criteria

• •Have an opioid use disorder of any severity
• •Have a greater than moderate substance use disorder on any other substance
• •Undergoing medication-assisted treatment for withdrawal of any substance
• •Have any medical conditions contraindicating SUVO (e.g., severe pulmonary disease, severe cardiovascular disease or clinically abnormal ECG, severe liver or kidney disease, seizure disorder, or sleep disorder -particularly narcolepsy)
• •Are currently taking medications with known drug interactions with SUVO (e.g., Monoamine oxidase (MAO) inhibitors, anticonvulsants, haloperidol, phenothiazines, anesthetics, and any sedative)
• •Are pregnant or breast feeding
• •BMI \> 30 (women only)
• •Have a current DSM-5 psychiatric disorder or neurological disease requiring on-going treatment that would make participation unsafe
• •Have history of seizure disorder
• •Have a head injury with loss of consciousness in the last 5 years