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Diclofenac Gel in the Treatment of Cervicogenic Headache | Clinical Trials | Clareo Health

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Diclofenac Gel in the Treatment of Cervicogenic Headache

Diclofenac Gel in the Treatment of Cervicogenic Headache: A Randomized, Double-Blind, Controlled Trial

NCT05312645•Loma Linda University

Summary

The intervention will consist of the nursing staff applying 2 grams of diclofenac 1% gel topically to the posterior cervical region four times daily. The control group will receive petroleum jelly topically to the posterior cervical region four times daily. Patients will receive a pre-intervention and post-intervention survey incorporating the Numeric Assessment Scale and Headache Impact Test-6.

Eligibility

Age

18 - 90 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. 18-90 Years old
•2. Subject must be able to consent for themselves
•3. Hospitalized at Loma Linda East Campus Rehabilitation Hospital
•4. English or Spanish speaking
•5. Complain of a headache, caused by a disorder of the cervical spine and/or it's component (i.e. bony, disc and/or soft tissue elements) usually but not invariably accompanied by neck pain (Avijgan et al, 2019)).

Exclusion Criteria

•1. Primary headache secondary to intracranial pathology (i.e. tumors)
•a. While TBI and Stroke patients can suffer headaches as a sequalae of their intracranial pathologies, it is not always the case that their headache is primarily secondary to their pathology but due to other etiologies such as cervicogenic headache or myofascial pain syndrome. History and physical examination by the medical team will help aid in determining the headache's etiology.
•2. Patients on dual antiplatelet therapy
•a. Aspirin 81mg daily or Clopidogrel (or antiplatelet monotherapy) is acceptable
•3. History of cervical spine procedures
•a. Spinal cord injury patients with cervical neck injuries that have required operative repair will be excluded from the study.
•4. Nerve blocks within past 4 weeks or steroid injections within past 6 months.
•5. Patients with fibromyalgia
•6. Pregnant women
•7. Chronic pain on continuous opiate regimen (use of opioids on most days \>90 days)
+6 more criteria

Locations (1)

Tom Vi and Zapara Rehabilitation Pavillion

Loma Linda, California, United States

Key Dates

Start Date

December 1, 2023

Primary Completion Date

August 21, 2024

Completion Date

August 21, 2024

Last Updated

January 23, 2025

Conditions

Cervicogenic Headache

Interventions

Diclofenac 1% Topical

DRUG

Petroleum Jelly

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 23, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Diclofenac Gel in the Treatment of Cervicogenic Headache

Inclusion Criteria

Exclusion Criteria

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