Earlier Diagnosis and Better Treatment Mission Related to the Cohort Programme

Exclusion Criteria

• •Refusal to sign the informed consent
• •Limited capacity of consent on the part of the donor, if there is no legally determined guardian/authorised representative, or the latter is not present or does not agree with the inclusion
• •Active cancer
• •Pregnant women
• •Underage subjects of less than 18 years of age
• •Refusal to comply with mandatory sample collection
• •For invasive procedures, i.e., lumbar puncture and skin biopsy: relevant blood clotting impairment, e.g., anamnestic evidence of frequent or prolonged bleedings.