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Assessment of Endogenous Oxalate Synthesis | Clinical Trials | Clareo Health

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COMPLETEDNANCT05229952

Assessment of Endogenous Oxalate Synthesis

This study aims to determine the daily rate of endogenous synthesis of oxalate using carbon 13 oxalate isotope tracer technique and a low-oxalate controlled diet.

Lead sponsor: University of Alabama at Birmingham•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of Alabama at Birmingham

Urinary oxalate excretion is derived from both dietary sources and endogenous synthesis. This study will use low-oxalate controlled diet and intravenous infusion of the isotope tracer carbon 13 oxalate, timed with blood and urine collections, to determine the daily rate of endogenous oxalate synthesis in non-stone forming volunteers and in subjects with calcium oxalate kidney stones. A DXA scan will be used to assess body composition.

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Mentally competent adults, able to read and comprehend the consent form
•Body Mass Index (BMI) between 18.5 and 50 kg/m2
•Acceptable 24 hour urine collections (judged on screening)
•good health as judged from a medical history, reported medications, and a complete blood metabolic profile
•with or without history of calcium oxalate kidney stones

Exclusion Criteria

•History of any hepatic, bowel, or endocrine disease or other condition that may influence the absorption, transport or urine excretion of ions
•Abnormal urine chemistries or blood metabolic profiles
•Poor 24 hour urine collections completed during screening, judged by 24 hour urine creatinine excretion (indicative of not collecting all urine in the 24 hour period)
•Pregnancy, intention to become pregnant in the near future, or lactation
•Aged lower than 18 or greater than 75 years
•BMI lower than18.5 or greater than 50 kg/m2

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 13, 2025Terms

Trial snapshot

StatusCOMPLETED

PhaseNA

Enrollment23

Start dateFeb 2022

Last updatedMay 13, 2025

Condition

Healthy Kidney Stone Obesity

Locations shown

University of Alabama at Birmingham

Birmingham, Alabama

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 13, 2025Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions