Chronotherapy of 5-Aminosalicylic Acid in Ulcerative Colitis

Exclusion Criteria

• •1. Active UC at enrollment (Mayo \> 2 and/or sigmoidoscopy score of 2 or 3)
• •2. Regular use of suppositories or enemas within the last 3 months
• •3. Use of biologics or immunomodulatory medications ( i.e. infliximab, Adalimumab, azathioprine, Vedolizumab, methotrexate, etc.)
• •4. Prior ostomy or subtotal colectomy
• •5. Recent prednisone or antibiotic use in last 12 weeks
• •6. Major Depression identified as Beck Depression Inventory (score ≥21)
• •7. Restless leg syndrome (score ≥ 15 on the IRLS Study Group Rating Scale)
• •8. Sleep apnea (score high risk ≥ 2 or more categories on the Berlin Questionnaire)
• •9. Clinically significant diabetes (Hgb-A1c\>7)
• •10. Regular use of medications that affect intestinal permeability, intestinal motility and/or NSAIDs 4 weeks prior to the study
• •11. Clinically significant cardiac, renal (creatinine \> twice normal) or liver disease
• •12. Alcohol use disorder (AUDIT\>8)
• •13. Chronic use of illicit drugs
• •14. Shift Work
• •15. Inability to sign an informed consen