Comparative Pharmacokinetic, Pharmacodynamic, and Safety Study of 1 Dose Level of Aspirin for Injection and Oral Aspirin Tablets in Healthy Adult Human Subjects

Exclusion Criteria

• •Subjects meeting any of the following criteria will be excluded from the study:
• •1. The subjects has had any major illness within 3 months before dosing with study drug or any significant ongoing chronic medical illness, as judged by the investigator.
• •2. The subjects has a history of active deep vein thrombosis and/or thromboembolic disorder, including history of hypothrombinemia and vitamin K deficiency.
• •3. The subject has a history of neuropsychiatric disease, hypertension, cardiac failure, cerebrovascular disease, chronic respiratory disease, asthma, nasal polyps associated with asthma, hepatic or renal impairment, recent dehydration (within last 30 days), gout thyrotoxicosis or systemic lupus erythematosus and other connective tissue disorders.
• •4. The subject has a history of gastrointestinal bleeding or has active gastrointestinal disease that could affect drug absorption.
• •5. The subject has a history of hemorrhagic disorder.
• •6. Prothrombin time or activated partial thromboplastin time level outside the normal range at screening and check-in.
• •7. The subject has an increased risk of bleeding including but not limited to: any history of a clinically significant bleeding problem, any recent (within 30 days preceding the first dose of study drug) major trauma, platelet count \<100,000 mm3
• •8. The subject has a history of glucose-6-phosphate dehydrogenase deficiency.
• •9. The subject has a recent history of tooth extraction within 3 weeks before dosing with study drug.
• •10. The subject is a smoker or has used nicotine-containing products (e.g., snuff, nicotine patch, nicotine chewing gum, mock cigarettes, inhalers, or "vape" devices) within 6 months before the first dose of study drug and throughout the study (including the washout period).
• •11. The subject has a history of alcohol abuse or drug addiction within 1 year prior to check-in or excessive alcohol consumption (regular alcohol intake \>21 units per week for male subjects and \>14 units of alcohol per week for female subjects), or use of alcohol 48 hours before dosing with study drug.
• •12. The subject has a positive test result for drugs of abuse, alcohol, or cotinine at screening or before dosing with study drug.
• •13. The subject has used any prescription (excluding hormonal birth control) or over-the-counter medications, including fish oil and other herbal or nutritional supplements and, in particular, aspirin (no aspirin-containing medications allowed at all), nonsteroidal anti-inflammatory agents (No NSAIDS allowed at all, and no acetaminophen, diclofenac, ketorolac allowed), or anticoagulation therapy within 14 days before dosing with study drug and throughout the entire study period (including the washout period).
• •14. The subject has received vaccination against Varicella zoster within 6 weeks before dosing with study drug.
• •15. The subject has a positive test result for COVID-19, hepatitis B surface antigen, hepatitis C virus antibody, or HIV type 1 or 2 antibodies at screening.
• •16. The subject has received the COVID-19 vaccine within 14 days before Day -3, or subjects who plan to receive a COVID-19 vaccine at any time during the study.
• •17. The subject has a history of relevant drug and/or food allergies (i.e., allergy to aspirin or any excipients, allergic skin reactions, or any significant food allergy that could preclude a standard diet in the clinical unit).
• •18. The subject has consumed grapefruit or grapefruit juice, Seville orange or Seville orange-containing products (e.g. marmalade), or alcohol-, caffeine-, poppy-, or xanthine-containing products within 48 hours.
• •19. The subject is involved in strenuous activity or contact sports within 24 hours before dosing with study drug and during the study.
• •20. The subject has donated blood or blood products \>450 mL within 30 days before dosing with study drug.
• •21. The subject has received study drug in another investigational study within 30 days or 5 half-lives, whichever is longer, before dosing with study drug.
• •22. In the opinion of the investigator, the subject is not suitable for entry into the study.
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