1. Already taking 5 or more anti-hypertensive medications (any class)

2. Unwillingness to change anti-hypertensive medication by the attending Nephrologist or patient

3. Recent acute kidney injury (\>50% increase in serum creatinine in preceding 30 days)

4. Previous kidney replacement therapy (kidney transplant, hemodialysis or peritoneal dialysis)

5. Recent myocardial infarction, stroke, heart failure (in preceding 30 days)

6. Recent injurious fall requiring hospitalisation (in preceding 30 days)

7. Concomitant major illness / comorbidity that may result in death in the next 6 months

8. Participation in another study that is likely to affect BP levels

9. Inability to provide consent due to cognitive impairment.

CENtral Blood Pressure Targeting: A Pragmatic RAndomized Pilot triaL in Advanced Chronic Kidney Disease