Lead Sponsor

Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•1. Over 18 years of age;
•2. eGFR \<30 mL/min/1.73m2 as determined by the CKD-EPI equation (within 30 days of screening);
•3. Office brachial cuff systolic blood pressure between 120 and 160 mmHg (using automated office blood pressure).

•1. Already taking 5 or more anti-hypertensive medications (any class)
•2. Unwillingness to change anti-hypertensive medication by the attending Nephrologist or patient
•3. Recent acute kidney injury (\>50% increase in serum creatinine in preceding 30 days)
•4. Previous kidney replacement therapy (kidney transplant, hemodialysis or peritoneal dialysis)
•5. Recent myocardial infarction, stroke, heart failure (in preceding 30 days)
•6. Recent injurious fall requiring hospitalisation (in preceding 30 days)
•7. Concomitant major illness / comorbidity that may result in death in the next 6 months
•8. Participation in another study that is likely to affect BP levels
•9. Inability to provide consent due to cognitive impairment.