BOTOX® Cosmetic and Skin Health.

Exclusion Criteria

• •1. Current Pregnancy or lactation \[sexually active women of childbearing age must agree to use medically acceptable methods of contraception for the duration of this study (e.g., oral contraceptives, condoms, intrauterine device, shot/injection, patch)\];
• •2. Patients meeting any official BOTOX® Cosmetic contra-indications;
• •3. Inability to comply with follow-up and abstain from other treatments in the region of interest during the study period;
• •4. Heavy smokers, classified as smoking more than 12 cigarettes per day;
• •5. History of severe or multiple allergies manifested by anaphylaxis;
• •6. Previous tissue revitalization therapy in the treatment area within 6 months before treatment with laser or light, mesotherapy, radiofrequency, ultrasound, cryotherapy, chemical peeling, or dermabrasion;
• •7. Previous treatment with neurotoxins in the area under assessment, within 6 months prior to enrolment;
• •8. Previous treatment with soft tissue fillers in the area under assessment, within 6 months prior to enrolment;
• •9. Subjects presenting with known allergy to BOTOX® Cosmetic.
• •10. Subjects presenting with porphyria.
• •11. Subjects with active disease, such as inflammation, infection or tumors, in or near the intended treatment site.
• •12. History of bleeding disorders or treatment with thrombolytics, anticoagulants, or inhibitors of platelet aggregation (e.g. Aspirin or other non-steroid anti-inflammatory drugs \[NSAIDs\]), within 2 weeks before treatment.
• •13. Subjects using immunosuppressants.
• •14. Subjects prescribed systematic or topical (in the area under assessment) antibiotics within 1 month of enrolment.
• •15. Tattoos, piercings or visible markings that in the treating investigator's opinion, may interfere with results or assessments.
• •16. Cancer or precancer in the treatment area, e.g. actinic keratosis.
• •17. Patients with a tendency to form hypertrophic scars or any other healing disorders.