Proof of Concept Study of MTC896 Gel to Reduce Sebum Production on the Forehead of Healthy Male Volunteers

Exclusion Criteria

• •1\. Have any visible skin disease at the application site which, in the opinion of the investigator, will interfere with the study evaluations;
• •2\. Have a history of photosensitive reactions or a history of cutaneous or systemic lupus or other disorders frequently associated with photosensitivity;
• •3\. Are not willing to refrain from using systemic/topical analgesics such as aspirin (81 mg daily aspirin will be allowed at the discretion of the PI), Aleve, Motrin, Advil, or Nuprin for 24 hours prior to and during the study (use of acetaminophen will be permitted);
• •4\. Are using systemic/topical corticosteroids in the test area for 3 weeks prior to and during the study, or systemic/ antihistamines for 24 hours prior to and during the study;
• •5\. Are using topical retinoids, products containing benzoyl peroxide, salicylic acid, or alpha-hydroxy acids for 2 weeks prior to and during the study; or systemic retinoids within 3 months prior;
• •6\. Are using any medication which, in the opinion of the investigator, will interfere with the study evaluations;
• •7\. Have seborrheic dermatitis and/or active atopic dermatitis/eczema in or around the test sites;
• •8\. Have a known allergy and/or hypersensitivity to constituents present in the study products;
• •9\. Have damaged skin in or around the test sites, including sunburn, excessively deep tans, uneven skin tones, tattoos, scars, excessive hair, numerous freckles, or other disfigurations of the test site;
• •10\. Have received treatment for any type of internal cancer within 5 years prior to study enrollment;
• •11\. Have a history of, or are currently being treated for skin cancer;
• •12\. Are currently participating in any clinical testing; and/or
• •13\. Have received any investigational treatment(s) within 4 weeks prior to study enrollment.