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Efficacy and Safety of Oral Semaglutide 50 mg Once Daily in East Asian Participants With Overweight or Obesity
Novo Nordisk are doing this study to see if semaglutide tablets can be used as a treatment to help people living with overweight or obesity lose weight. This study will look at the change in participants' body weight. Participants will either get semaglutide tablets (new medicine) or placebo tablets ('dummy' medicine that looks like semaglutide but has no effect on the body). For a fair comparison, people are divided into two groups at random by a computer. This process is called randomisation. Semaglutide tablets are new medicine being tested to treat overweight and obesity. Doctors in many countries can already prescribe semaglutide tablets at lower doses to treat type 2 diabetes. Participants will get semaglutide or placebo tablets for 68 weeks and will need to take 1 tablet every morning. In addition to taking the medicine, participants will have talks with study staff about: * healthy food choices * how to be more physically active * what participants can do to lose weight The study will last for about 1½ year. Participants will have 14 clinic visits and 7 phone calls with the study healthcare professional. Blood samples will be taken at 12 visits. Women cannot take part if pregnant, breast-feeding or planning to get pregnant during the study period. If participants are a woman and are able to become pregnant, participants will be checked for pregnancy via urine tests.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Iryouhoujinsyadan Shoureikan Shinsapporo Seiryou Hospital
Sapporo, Hokkaido, Japan
Tsuruma Kaneshiro Diabetes Clinic
Yamato-shi, Kanagawa, Japan
OCROM Clinic
Suita-shi, Osaka, Japan
Naka Kinen Clinic
Ibaraki, Japan
Toranomon Hospital, Endocrinology and Metabolism
Minato-ku, Tokyo, Japan
Osaka University Hospital
Osaka, Japan
Takatsuki Red Cross Hospital
Osaka, Japan
Tokyo Center Clinic
Tokyo, Japan
ToCROM Clinic
Tokyo, Japan
Kyungpook National University Hospital
Daegu, South Korea
Start Date
November 16, 2021
Primary Completion Date
July 11, 2023
Completion Date
September 1, 2023
Last Updated
June 6, 2025
201
ACTUAL participants
semaglutide 50 mg
DRUG
placebo (semaglutide)
DRUG
Lead Sponsor
Novo Nordisk A/S
NCT06277232
NCT07395973
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT05301413