The Effects of a 4-week Supplementation With a Ketogenic Nutrient Mix on 24-hour Substrate Metabolism and Muscle Health

Exclusion Criteria

• •Type 2 diabetes
• •Participants with active congestive heart failure and/or severe renal and or liver insufficiency
• •Uncontrolled hypertension
• •Alcohol consumption of \>3 servings per day for men and \>2 servings per day for women
• •Unstable body weight (weight gain or loss \> 5 kg in the last 3 months) or intention to lose weight
• •Participants who are on an intermittent fasting diet
• •Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the investigator which would possibly hamper our study results
• •Significant food allergies/intolerance (seriously hampering study meals or study product)
• •Participants who do not want to be informed about unexpected medical findings
• •Blood donation during or within 2 months prior to the study
• •Disturbances in circadian rhythm determined with the follow criteria:
• •Extreme early bird or extreme night person (score ≤30 or ≥70 on MEQ-SA questionnaire)
• •Heavily varying sleep-wake rhythm
• •Night shift work during last 3 months
• •Travel across \> 1 time zone in the last 3 months
• •High daily caffeine intake \> 400mg (more than 4 cups of coffee or energy drinks)