Lead Sponsor

University of British Columbia

Age

All ages

Sex

ALL

Healthy Volunteers

Yes

•a Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM IV-TR; American Psychiatric Association (APA), diagnosis of major depressive disorder (MDD) without psychotic features, in Full Remission;
•three or more prior major depressive episodes;
•age between 18 and 65 years;
•cognitive reactivity (CR) or mood-activated dysfunctional beliefs score greater than or equal to eight (see assessment procedure below);
•a score of less than 10 on the Hamilton Rating Scale for Depression (HRSD);
•minimum of a 10 week period free of psychotropic medication other than stable dosage of antidepressant medication for a minimum of four weeks;
•fluency in English; An increased cognitive reactivity score of eight points or more and,
•ability to give informed consent and complete questionnaires unassisted.

•a diagnosis of bipolar disorder (past or present), schizophreniform disorders, substance abuse or dependence (current or within the past six months), borderline or antisocial personality disorder, or neurocognitive disorders;
•current psychotherapy or counselling more frequently than twice per month;
•current practice of meditation more than once per week or yoga more than twice per week;
•electroconvulsive therapy within the past six months; or
•self-reported ingestion of alcohol or other psychoactive substances within the past 48 hrs.