cArdiopulmonary exerCise Test Assessing Multiple bIOmarkers iN Type 1 Diabetes

Exclusion Criteria

• •Recently diagnosed T1D (\< 12mo)
• •Participants not on MDI or CSII
• •Musculoskeletal disorder that affects cycling or is a contra-indication for vigorous physical activity
• •Cardiorespiratory disease or ECG abnormality that is a contra-indication for vigorous physical activity
• •Having an acute illness (e.g. influenza) that interferes with glucose metabolism
• •Having a metabolic disorder (different from diabetes) or takes drugs known to have significant interference with glucose metabolism, such as systemic corticoids as judged by the investigator
• •Current treatment with drugs known to have significant interference with glucose metabolism, such as systemic corticoids as judged by the investigator
• •Presence of concomitant pathology such as heart failure, liver failure, kidney failure defined as eGFR \<45mL/min
• •Patient not able or willing to sign the patient informed consent