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Decreasing Long-term Opioid Use in Cancer Survivors | Clinical Trials | Clareo Health

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Decreasing Long-term Opioid Use in Cancer Survivors

Creating a Pathway for Disease-Free Cancer Survivors to Decrease Long-term Opioid Use

NCT05067556•Virginia Commonwealth University

Summary

This is a feasibility pilot trial assessing a behavioral intervention for chronic pain among disease-free cancer survivors to decrease long-term opioid dependence.

Detailed Description

To assess the feasibility and acceptability of implementing brief Acceptance and Commitment Therapy for chronic pain (ACT-CP) in a Survivorship clinic.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Diagnosis of cancer of any type, currently in remission, having completed active primary therapy. Patients on oral adjuvant hormone therapy will still be eligible.
•Completed active therapy must have been curative in intent (for example stage IV cancer patients such as head and neck cancer patients treated with curative intent are eligible).
•Self-reported cancer pain for \>= 3 months
•Opioid use \>= 5MME/day (morphine milligram equivalents) as prescribed by physician for cancer-related pain for at least 6 months beyond completion of their cancer treatment
•VCUHealth system patient

Exclusion Criteria

•History of opioid use prior to cancer diagnosis
•Anyone with prior history of substance use disorder or currently enrolled in a methadone program
•Anyone with schizophrenia or bipolar disorder
•Current utilization of psychotherapy services for pain, depression, anxiety, and/or PTSD
•Cognitive concerns that would prevent meaningful engagement in treatment
•Inability to converse in English
•Lack of working telephone and Internet connection (must have at least one or the other)
•Anyone found to have progression of cancer
•Anyone diagnosed with cancer recurrence or new cancer during their study period
•Documented diagnosis of or positive screen for current substance use disorder (score \>5 on the Drug Abuse Screening Test-10 \[DAST-10\])
+1 more criteria

Locations (1)

Virginia Commonwealth University

Richmond, Virginia, United States

Key Dates

Start Date

December 20, 2021

Primary Completion Date

March 30, 2028

Completion Date

March 30, 2028

Last Updated

August 8, 2025

Enrollment

ESTIMATED participants

Conditions

PainChronic PainCancer PainSurvivorship

Interventions

Acceptance and Commitment Therapy for chronic pain (ACT-CP)

BEHAVIORAL

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RECRUITINGPHASE1

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 8, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Decreasing Long-term Opioid Use in Cancer Survivors

Inclusion Criteria

Exclusion Criteria

Effect of Virtual Reality on Patient's Comfort During Cardiac Electronic Device Implantation.

A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis

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