A Trial of LY3056480 in Patients With SNLH

Exclusion Criteria

• •1. Presenting with a primary complaint of tinnitus
• •2. Any conductive hearing loss of greater than 15 dB at a single frequency or greater than 10 dB at two or more contiguous octave frequencies in the study ear
• •3. History of suspected or diagnosed genetic cause of hearing loss;
• •4. Partial deafness as defined as hearing loss in any frequency (up to 8 kHz) greater than 80dB
• •5. Suspected or known diagnosis of the following inner ear pathology, congenital hearing loss, fluctuating hearing loss, Ménière's disease, or secondary endolymphatic hydrops, perilymph fistula, cochlear barotrauma, autoimmune hearing loss, radiation-induced hearing loss, retro-cochlear lesion, ototoxicity
• •6. Evidence of acute or chronic otitis media or otitis externa on examination; or a history of middle ear pathology and/or surgery (except for ear tubes as a child)
• •7. Any therapy known as ototoxic
• •8. Participant in a previous trial of LY3056480