Lead Sponsor

Wayne State University

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•1. Self-identification as Black, age ≥18 years, living in the Detroit-area
•2. Systolic BP 110-139 and diastolic BP \<90 mm Hg upon screening
•3. Not currently taking medications for HTN
•4. Low cardiovascular risk as defined by 2017 AHA/ACC HTN guidelines (no diabetes, no chronic kidney disease, no established ASCVD
•5. 10-year ASCVD risk \<10% if systolic BP is in stage-1 hypertension range (130-139 mm Hg and \< 65 years old

•1. Any clinical cardiovascular disease (e.g., coronary artery disease, heart failure, stroke, arrhythmia)
•2. Chronic kidney disease or glomerular filtration rate \<60 ml/min on screening laboratory testing
•3. Diabetes or HbA1c ≥ 6.5% on screening laboratory testing
•4. LDL-C ≥ 190 mg/dL on screening laboratory testing (on or off medications)
•5. ASCVD risk score calculated ≥ 10% for 10 years by clinical calculator on screening (if stage-1 systolic HTN only)2
•6. Inability or not willing to follow-up with PAL2 research or usual care limb and at 6 \& 12-months at the MHU
•7. Taking any medications for diabetes, heart disease or kidney disease. Cholesterol medication is not an exclusion
•8. Inability to understand and sign informed consent
•10\. Chronic condition (e.g., cancer) with a potential life expectancy \< 2 years