Probiotics as Adjunctive Migraine Prophylaxis

Exclusion Criteria

• •1. Lactose intolerance
• •2. Previous history of small and large bowel surgery
• •3. Use of probiotics or antibiotics in 2 weeks before baseline visit.
• •4. Patients with medical conditions such as severe hypertension, infections,
• •5. Malignancy, cardiovascular and cerebrovascular diseases, epilepsy, degenerative central nervous system diseases, renal failure, hepatic failure, bleeding diathesis and serious mental illnesses
• •6. Headache with red flags symptoms that may suggest organic secondary headaches.
• •7. Onset of headache more than 50 years
• •8. Prior GI infection in the previous 3-months
• •9. Morbid obesity (BMI \>40)
• •10. Pregnant or lactating women