Left vs. Right Non-Inferiority Trial

Exclusion Criteria

• •1. have a history of substance use within the last 3 months;
• •2. have a concomitant major unstable medical illness;
• •3. have active suicidal intent;
• •4. are pregnant;
• •5. have a lifetime (MINI) diagnosis of any psychotic or bipolar disorder;
• •6. have a MINI anxiety disorder or personality disorder assessed by a study investigator to be primary and causing greater impairment than MDD;
• •7. have failed a course of ECT in the current episode;
• •8. have any significant neurological disorder, any history of seizure (except those therapeutically induced by ECT), significant head trauma with loss of consciousness for \> 5 min;
• •9. have any intracranial implant (e.g., aneurysm clips) or any other metal object within or near the head, excluding the mouth, that cannot be safely removed;
• •10. are participating in psychotherapy, must have been in stable treatment for at least 3 months prior to study entry, with no anticipated change in the frequency of therapeutic sessions, or focus of therapeutic sessions over the duration of the study;
• •11. have a clinically significant laboratory abnormality, in the opinion of the one of the principal investigators;
• •12. have a non-correctable clinically significant sensory impairment (i.e., cannot hear well enough to cooperate with interview);