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Evaluate the Efficacy and Safety of MUSK Pill on Coronary Microvascular Dysfunction | Clinical Trials | Clareo Health

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Evaluate the Efficacy and Safety of MUSK Pill on Coronary Microvascular Dysfunction

A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Shexiang Baoxin Pill on Coronary Microvascular Dysfunction

NCT04984954•Shanghai Hutchison Pharmaceuticals Limited

View on ClinicalTrials.gov

Summary

Objective to evaluate the effect of Shexiang Baoxin Pill on myocardial ischemia in patients with coronary microvascular dysfunction (non obstructive coronary heart disease) through a randomized, double-blind, placebo-controlled clinical multicenter study.At the same time, the effects of exercise tolerance and quality of life were also observed.

Eligibility

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Patients aged 18-80, male or female;
•2. Selective coronary angiography or coronary CTA showed that the diameter of coronary artery ≥ 2.5mm, the degree of stenosis \< 50%, without myocardial bridge;
•3. They were able to perform treadmill exercise, and the treadmill test (EET) was positive;
•4. Angina pectoris was found;
•5. Patients are willing to follow up and sign informed consent; All the above criteria should be met.

Exclusion Criteria

•1. Coronary heart disease complicated with hypertrophic cardiomyopathy;
•2. There was a history of AMI, PCI and CABG, and myocardial bridge was found by angiography or CTA;
•3. Patients with severe medical diseases (liver, kidney, hematopoietic system and other serious primary diseases, etc.);
•4. Mental disorders and mental diseases;
•5. Patients with pulmonary failure and NYHA heart function grade III-IV, unable to carry out exercise test;
•6. Contraindications of Shexiang Baoxin Pill: forbidden for pregnant women;
•7. Those who have known history of allergy to Shexiang Baoxin Pills;
•8. Recently, the patient has taken Shexiang Baoxin Pill and other anti ischemic traditional Chinese medicine regularly, or it contains borneol, toad venom and other ingredients in Shexiang Baoxin Pill;
•9. Combined with frequent ventricular premature beats, ventricular tachycardia, atrial fibrillation, sinoatrial block, atrioventricular pathway block, left bundle branch block and right bundle branch block, which may affect the judgment of exercise ECG results;

Locations (1)

Huashan Hospital Fudan University

Shanghai, Shanghai Municipality, China

Key Dates

Start Date

January 28, 2021

Primary Completion Date

December 31, 2023

Completion Date

June 30, 2024

Last Updated

August 2, 2021

Enrollment

264

ESTIMATED participants

Conditions

Angina PectorisCoronary Heart DiseaseX Syndrome, AnginaNon Obstructive Coronary Artery Disease

Interventions

MUSK pill

DRUG

Contacts

HaiMing Shi, doctor

CONTACT

+8613901824859 13901824859@163.com

Ying Shan, doctor

CONTACT

+8613402021699 shanyingli@yahoo.com

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 2, 2021Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Evaluate the Efficacy and Safety of MUSK Pill on Coronary Microvascular Dysfunction

Inclusion Criteria

Exclusion Criteria

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