High Fiber in Parkinson's Disease

Exclusion Criteria

• •Occupation expected to change the microbiome (e.g. sanitation worker)
• •Treatment with medications that may induce parkinsonism (e.g. metoclopramide, typical or atypical antipsychotic agents)
• •Treatment within 12 weeks with oral or intravenous antibiotics
• •Known diagnosis of inflammatory bowel disease
• •Symptomatic organic gastrointestinal (GI) disease (other than hemorrhoids and hiatal hernia) or abdominal surgeries for symptomatic gastrointestinal disease such as bowel resection, diverticular surgery, colostomy; subjects with a history of an appendectomy or gallbladder removal for non-cancerous disease more than 5 years prior to presentation are allowed.
• •Symptomatic functional GI disease that significantly impairs intestinal motility such as scleroderma or use of GI motility drugs
• •Acute illness requiring immediate hospitalization
• •Pre-existent conditions as below:
• •Liver disease (cirrhosis or persistently abnormal AST or ALT that are 2X\> normal);
• •Kidney disease (creatinine\>2.0 mg/dL);
• •Uncontrolled psychiatric illness;
• •Clinically important lung disease or heart failure;
• •HIV disease;
• •Alcoholism, unreliable drinking history; or consumption of alcohol more than 3 times a week or binge drinking or drinking more than or equal to 3 drinks per occasion;
• •Transplant recipients;
• •Diabetes;
• •BMI \> 30
• •Clinically significant dehydration or clinically detectable ascites or peripheral edema or cardiac failure
• •Presence of short bowel syndrome or severe malnutrition with ideal body weight \< or = 90%
• •Use of immunosuppressive medications in 3 months prior to enrollment
• •Anti-inflammatory medication use within 3 weeks of enrollment.
• •Chronic use of diuretics