Lead Sponsor

Wuerzburg University Hospital

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•age ≥18 years
•adrenal incidentaloma (≥ 1cm) detected by cross-sectional imaging between January 1, 1996 and December 31, 2015
•imaging characteristics suggestive for an adrenal adenoma or excluded malignancy by follow-up imaging
•availability of a 1 mg dexamethasone test result
•follow-up data on living status and occurrence of cardiovascular events
•follow-up duration of at least 36 months.

•proven pheochromocytoma, primary hyperaldosteronism or adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome
•clinical features suggestive for overt Cushing's syndrome; urinary free cortisol (UFC) ≥ 2-fold higher than the upper limit of normal of the local assay
•any active malignancy (including adrenocortical cancer) at the time of primary diagnosis