Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)

Exclusion Criteria

• •History of breast or endometrial cancer
• •Estrogen therapy in the past 3 months
• •Baseline hematocrit \>48%.
• •Serum creatinine \>2.5 mg/dL.
• •HbA1c \>9.0%. Subjects on insulin therapy will be excluded.
• •BMI \>40 kg/m2.
• •Uncontrolled congestive heart failure.
• •Myocardial infarction, acute coronary syndrome, revascularization surgery or stroke within the past 3 months.
• •History of genetic thromboembolic disorder.
• •Diagnosis of bipolar disorder or schizophrenia.
• •Use of testosterone, spironolactone, finasteride or systemic ketoconazole in the past 3 months.