Citrate Versus Heparin in Continuous Renal Replacement Therapy :

Exclusion Criteria

• •patients with previous history of chronic kidney disease (CKD) (baseline serum creatinine \> 2 mg/dL (male) or \> 1.5 mg/dL (female)
• •history of renal transplantation
• •known pregnancy
• •previous dialysis within 30 days
• •severe liver disease
• •end stage heart disease or untreatable malignancy
• •moribund patients with expected survival less than 30 days
• •previous use of heparin or other anticoagulant, antiplatelet within 7 day except use for deep vein thrombosis
• •active bleeding at the time of enrollment and/or severe coagulopathy
• •receiving blood or blood components prior to enrollment
• •hemoglobin less than 7.5 g/dL and/or platelet count less than 100,000/mm3
• •previous underlying clotting disorders such as hypercoagulable state
• •severe malnutrition (Body mass index (BMI ) less than 18)
• •underwent CRRT for other reasons besides acute kidney injury (AKI)