Moderate - Severe Th2 (Type 2) High asthma, as defined by Forced Expiratory Volume in one second (FEV1) \<90% predicted, on medium to high dose inhaled corticosteroids (ICS) with or without a second controller
Age \> 18
Inhaled steroid doses of 500micrograms (mcg) per day or more (Fluticasone equivalent)
Reversibility \>/= 12% at screening or within the past 2 years, or a positive methacholine challenge test within the past 2 years, or a positive methacholine challenge during screening
FEV1/Forced Vital Capacity (FVC)\<75%
Blood Eosinophils (EOS) \>300 cells per mm3
Exhaled Nitric Oxide (FeNO) \>25 parts per billion (ppb)
Asthma Control Test (ACT) score \<20
You may not be if
Pregnant, nursing, or unwilling to test for pregnancy
Current smoker or \>10 pack year smoking history
Body Mass Index (BMI)\>37
Respiratory infection in the last 30 days
Use of antibiotics or oral prednisone in the last 30 days
Current or previous use of dupilumab
Current or recent use of anti-IL-5 therapies
Any other criteria that place the subject at unnecessary risk
Diagnosis of other lung diseases including Chronic Obstructive Pulmonary Disease (COPD)
History of non-skin cell cancer in the last 5 years
