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COMPLETEDPhase 1/2NCT04718727

Olanzapine for the Prevention of Postoperative Nausea and Vomiting

Nausea and vomiting (PONV) remain a common problem in surgical units. Even after two or three prophylactic antiemetic interventions, patients with all four of the Apfel risk factors for PONV have an e...

Lead sponsor: Amani Hassan Abdel-Wahab•2 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Amani Hassan Abdel-Wahab

Aim of the Research, to compare the effects of oral 10 and 5 mg Olanzapine for the Prevention of Postoperative Nausea and Vomiting

Age

18 - 50 years

Sex

FEMALE

Healthy Volunteers

No

Inclusion Criteria

•ASA I and II patients
•undergoing ambulatory laparoscopic gynecologic surgery with general anesthesia
•patients have at least two of the four Apfel risk factors for PONV2
•Lack of history of psychiatric and psychotic illnesses.

Exclusion Criteria

•ASA III and ≥ IV patients
•Psychological diseases
•History of chemotherapy
•have a pre-existing vestibular disorder or history of dizziness or preexisting nausea or vomiting in the 24 h before surgery, or were being treated with regular antiemetic therapy including systemic corticosteroids.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: March 9, 2023Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE1/PHASE2

Enrollment132

Start dateMar 2021

Last updatedMar 9, 2023

Condition

Postoperative Nausea

Locations shown

Assiut university hospitals

Asyut, Assiut Governorate

Assiut university

Asyut

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 9, 2023Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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