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Effects of taVNS Combined With Dexmedetomidine on POVN | Clinical Trials | Clareo Health

RECRUITINGNA

Effects of taVNS Combined With Dexmedetomidine on POVN

The Effect of Dexmedetomidine Combined With Percutaneous Auricular Vagus Nerve Stimulation on Postoperative Nausea and Vomiting in Female Laparoscopic Patients: A Randomized Controlled Trial

NCT07271147•Affiliated Hospital of Nantong University

View on ClinicalTrials.gov

Summary

To explore the effects and possible mechanisms of dexmedetomidine combined with taVNS on the incidence of postoperative nausea and vomiting in female patients undergoing laparoscopic surgery

Detailed Description

Patients are recruited one week prior to the start of the trial, during which they are informed about the experimental protocol and associated risks. After obtaining informed consent and signatures, they are enrolled as study participants. Patients who meet the trial criteria are randomly assigned in a 1:1 ratio to the control group (sham taVNS group) and the intervention group (taVNS group, with taVNS intervention starting 30 minutes prior to anesthesia induction and continuing until the end of surgery, terminating after the removal of the endotracheal tube in the PACU), in a double-blind manner (with taVNS intervention and postoperative follow-up conducted by different researchers).

Eligibility

Age

18 - 65 years

Sex

FEMALE

Healthy Volunteers

Inclusion Criteria

•Women aged 18 to 65;
•Elective laparoscopic surgery under general anesthesia;
•Classified as American Society of Anesthesiologists (ASA) physical status I to II;
•Capable of understanding the study procedures and various assessment scales and able to effectively communicate with the researchers;
•Willing to participate in the study and provide written informed consent.

Exclusion Criteria

•Patients with ASA anesthesia classification ≥ III;
•Poorly controlled hypertension, atrioventricular block ≥ second degree, obesity (BMI \> 30 kg/m²);
•Pregnant or breastfeeding;
•Known allergy to drugs used in the study protocol, history of traumatic brain injury, history of gastrointestinal surgery;
•Liver or kidney dysfunction (liver enzymes or creatinine ≥ 1.5 times the normal value), alcoholism or drug abuse, mental illness, use of antiemetics, opioids, psychoactive drugs, or corticosteroids within 24 hours before surgery;
•Patients with implanted stimulators (such as pacemakers, implantable vagus nerve stimulators, deep brain stimulators, spinal cord stimulators, etc.), cochlear implants, or metal implants (except in dental cases);
•Skin lesions or dermatological diseases at the site of electrical stimulation;
•Preoperative heart rate \< 50 bpm or the presence of sinoatrial node disease or second-degree or higher atrioventricular block;
•Patients unable to cooperate with assessments;
•Patients participating in other clinical trials.

Locations (1)

Affiliated hospital of Nantong University

Nantong, Jiangsu, China

Key Dates

Start Date

November 7, 2025

Primary Completion Date

December 1, 2026

Completion Date

December 1, 2026

Last Updated

December 9, 2025

Enrollment

176

ESTIMATED participants

Conditions

Postoperative Nausea and Vomiting

Interventions

Transcutaneous Auricular Vagus Nerve Stimulator

DEVICE

Dexmedetomidine

DRUG

Contacts

Chao-Chao Zhong, M.D.;P.h.D

CONTACT

15152460489 zhong249767626@163.com

Paragastric Block for Pain and PONV in Sleeve Gastrectomy

NCT07274215

Postoperative Nausea and VomitingPostoperative Pain After Laparoscopic Sleeve Gastrectomy

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RECRUITINGNA

Early Oral Fluid Intake in Children After Day Surgery

NCT06937684

Pediatric AnesthesiaPostoperative Nausea and Vomiting (PONV)+1 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 9, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effects of taVNS Combined With Dexmedetomidine on POVN

Inclusion Criteria

Exclusion Criteria

Paragastric Block for Pain and PONV in Sleeve Gastrectomy

Early Oral Fluid Intake in Children After Day Surgery

Pregabalin in the Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy (LSG).

Effect of Implementing Snap-needle Therapy Combined With Ginger Paste During Anesthesia Recovery on the Recovery of Gastrointestinal Function After Gynecologic Laparoscopy

The Correlation Between Intraoperative End Tidal Carbon Dioxide, Perfusion Index and Pulse Variability Index on Postoperative Nausea Vomiting and Pain

Chewing Gum vs. Ondansetron as Rescue Treatment for PONV in Female Patients